Intrauterine Platelet Rich Plasma (PRP) Infusion for Endometrial Insufficiency: A Prospective, Double-Blind, Placebo-Controlled Randomized Controlled Trial
Reproductive Medicine Associates of New Jersey
Summary
To determine the effectiveness of an intrauterine PRP infusion on endometrial thickness and in vitro fertilization (IVF) outcomes in a population of infertile women with a history of unresponsive thin endometrium.
Description
Patients with a history of thin endometrium will be randomized to either an intrauterine infusion of PRP vs. a placebo infusion of normal saline. This is a double-blind, placebo controlled prospective RCT. Patients will then proceed with a frozen embryo transfer of a single euploid embryo per routine.
Eligibility
- Age range
- 18–45 years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Patients who have previously undergone at least 2 unsuccessful frozen embryo transfer cycles, defined as failure to achieve a sustained clinical pregnancy (visualization of intrauterine gestational sac on ultrasound or a cancelled embryo transfer cycle due to inadequate endometrial thickness * Patients with a diagnosis of thin endometrial lining (less than or equal to 6 mm maximum thickness) during prior unsuccessful or canceled embryo transfer cycles. Exclusion Criteria: * Fewer than 2 prior unsuccessful or canceled frozen embryo transfer cycles. * Most recent unsucce…
Interventions
- OtherPlatelet Rich Plasma Intrauterine infusion
an intrauterine infusion of platelet rich plasma (PRP) will be administered to this group of participants
- OtherNormal saline Intrauterine infusion
an intrauterine infusion of normal saline will be administered to this group of participants
Location
- Reproductive Medicine Associates of New JerseyBasking Ridge, New Jersey