Expression of Stress Markers in MSM Living With HIV Receiving Contingency Management for Methamphetamine Use Disorder
University of California, Los Angeles
Summary
This is a non-randomized behavioral trial that aims to investigate whether changes in inflammatory and type I IFN expression coincide with changes in methamphetamine use and viral load over the course of 12 weeks in HIV-positive people assigned male at birth with and without methamphetamine use disorder.
Description
This is a within-subjects, two-arm study with 35 HIV-positive people assigned male at birth receiving contingency management for treatment of methamphetamine use disorder and 20 HIV-positive people assigned male at birth serving as a non-substance-using healthy control (N=55 total). HIV-positive participants with methamphetamine use disorder who meet the eligibility criteria will be assigned to the contingency management treatment group. HIV-positive participants who do not use substances and meet the specific criteria will be assigned to the non-substance-using control group. Participants wil…
Eligibility
- Age range
- 18–45 years
- Sex
- Male
- Healthy volunteers
- Yes
Inclusion Criteria: For Contingency Management: 1. Assigned male sex at birth 2. 18 to 45 years of age 3. Reports having sex with men in the past 12 months. 4. HIV-positive (confirmed by certification or by HIV rapid test) 5. Has an HIV care provider (last seen in the past 12 months) 6. Has a current antiretroviral prescription 7. Meets the DSM-5 criteria for methamphetamine use disorder using SCID-5 8. Urine test is positive for methamphetamine within 30 days of their screening visit 9. Seeking treatment for methamphetamine use disorder. 10. Ability to attend twice weekly appointments for d…
Interventions
- BehavioralContingency Management
A positive reinforcement behavioral treatment with escalating rewards for consecutive negative urine tests, starting at $10 and capped at a maximum of $40 per negative result.
Location
- UCLA Vine Street ClinicLos Angeles, California