Gut Microbiome and Blood Indices in Patients With AD and Their Spousal Caregivers
University of Virginia
Summary
Spousal caregivers of Alzheimer's Dementia (AD) patients have an elevated risk of developing AD in the future. Past studies have shown the presence of serum indicators correlated with gut biome dysfunction in AD patients. We hypothesize that the same gut biome dysfunction may be present in spousal caregivers of AD patients.
Description
Patients with Alzheimer's disease (AD) have gut dysbiosis. Short-chain fatty acids (SCFAs) are products of the gut microbiome. Among them, Acetate and valeric acid were positively correlated with the Aβ plaque load detected by amyloid PET in participants with or without AD. However, the levels of SCFAs in the blood of patients with AD have not been defined. Also, the usefulness of indices of inflammation and neuropathology in the blood as biomarkers for cognitive impairment in patients with AD is elusive. Importantly, spousal caregivers of patients with dementia have a higher risk of developin…
Eligibility
- Age range
- 65–90 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. patients with AD whose clinical dementia rating (CDR) is \> 1 2. Spouses of Patients in the above group Or 3. Healthy adult unrelated to groups 1 and 2, with no history of dementia And 4. Regardless of the grouping, the prospective subject must be between 65 and 90 years old Exclusion Criteria: 1. Familial Alzheimer's Disease (AD) 2. Severe cardiovascular disease 3. Severe respiratory system disease 4. Severe liver disease 5. Severe kidney disease 6. Severe central nervous system diseases 7. Having a lifespan of fewer than 3 months 8. History of psychiatric illness 9.…
Location
- University of VirginiaCharlottesville, Virginia