Endocrine Therapy-Induced Alopecia Natural History Evaluation Among Female Breast Cancer Survivors
Mayo Clinic
Summary
This study evaluates endocrine therapy-induced alopecia among postmenopausal and premenopausal female patients with breast cancer. Alopecia is one of the most feared side effects of cancer-directed therapy, causing distress in women starting treatment for breast cancer. While alopecia is a well-known side effect of many chemotherapy drugs, it has also been reported by women undergoing endocrine therapy. Despite the frequent reports of alopecia related to endocrine therapy, hair loss is rarely reported as a side effect of endocrine therapy and the exact characterization of alopecia is not well understood. By having postmenopausal and premenopausal breast cancer patients describe their hair loss symptoms experienced while undergoing endocrine therapy, researchers may be able to better characterize the incidence, timing, duration, and severity of alopecia and whether the different types of endocrine therapy cause more or less trouble in this regard.
Description
PRIMARY OBJECTIVE: I. To describe the incidence, characteristics, and severity of alopecia related to endocrine therapy in four cohorts of postmenopausal women who have had a diagnosis of breast cancer: patients undergoing endocrine therapy with tamoxifen, patients undergoing endocrine therapy with an aromatase inhibitor, patients undergoing therapy with an aromatase inhibitor in addition to a CDK4/6 inhibitor, and patients not receiving endocrine therapy. A fifth cohort has met the accrual goal and is no longer enrolling: premenopausal women receiving any type of endocrine therapy. SECONDAR…
Eligibility
- Age range
- 18+ years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Age \>= 18 years * Women with a diagnosis of breast cancer who are being treated with curative intent, with the one exception being women who are receiving CDK4/6 inhibitors (these patients being allowed to have more advanced disease) * Provide informed consent * Ability to complete questionnaire(s) by themselves or with assistance * Filling into one of the 5 groups (understanding that groups will close once they complete their accrual goals of 30 patients) * Willingness to complete questionnaires every 3 months * Ability to complete the first questionnaire within 2 week…
Interventions
- OtherElectronic Health Record Review
Ancillary studies
- OtherQuestionnaire Administration
Complete alopecia questionnaires
- OtherSurvey Administration
Complete alopecia surveys
Locations (23)
- Mayo Clinic Health System in Albert LeaAlbert Lea, Minnesota
- Essentia Health Baxter ClinicBaxter, Minnesota
- Sanford Joe Lueken Cancer CenterBemidji, Minnesota
- Essentia Health Saint Joseph's Medical CenterBrainerd, Minnesota
- Essentia Health - Deer River ClinicDeer River, Minnesota
- Essentia Health Saint Mary's - Detroit Lakes ClinicDetroit Lakes, Minnesota