Auburn University
The goal of this clinical study is to test the effectiveness of a supplemental fMRI neurofeedback and/or TMS intervention in individuals seeking treatment for Alcohol Use Disorder. After an initial visit, participants will come in once a week for four (4) weeks for an intervention session, which may or may not include TMS and MRI. Participants will be contacted for monthly follow-ups (remotely) for up to 12 months and will be asked to come in for two MRI follow-ups at 6 and 12 months.
Inclusion Criteria: 1. Age 19-65 2. Receiving treatment for Alcohol Use Disorder Exclusion Criteria: 1. MRI Contraindications 1. Presence of metal in the body that would make having a 7T MRI unsafe (including facial tattoos) 2. Claustrophobia, such that individual would be unable to stay in the MRI for up to 1 hr 3. Hearing loss, including tinnitus, that might be made worse by MRI or TMS 2. TMS Contraindications 1. Has ever had a seizure, or has a family history of epilepsy 2. Taking medications or substances that lower the seizure threshold 3. Implanted devices that are…
fMRI aided reinforcement of craving regulation
rTMS to right dorsolateral prefrontal cortex to reduce craving
Display of feedback from other participant's sessions to serve as a sham for fMRI aided reinforcement of craving regulation
rTMS using placebo coil (no brain stimulation, emulates other features of active TMS), placed over right dorsolateral prefrontal cortex
Arctuva estimate
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