A Combined Neurofeedback-TMS Intervention for Alcohol Use Disorder
Auburn University
Summary
The goal of this clinical study is to test the effectiveness of a supplemental fMRI neurofeedback and/or TMS intervention in individuals seeking treatment for Alcohol Use Disorder. After an initial visit, participants will come in once a week for four (4) weeks for an intervention session, which may or may not include TMS and MRI. Participants will be contacted for monthly follow-ups (remotely) for up to 12 months and will be asked to come in for two MRI follow-ups at 6 and 12 months.
Eligibility
- Age range
- 19–65 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Age 19-65 2. Receiving treatment for Alcohol Use Disorder Exclusion Criteria: 1. MRI Contraindications 1. Presence of metal in the body that would make having a 7T MRI unsafe (including facial tattoos) 2. Claustrophobia, such that individual would be unable to stay in the MRI for up to 1 hr 3. Hearing loss, including tinnitus, that might be made worse by MRI or TMS 2. TMS Contraindications 1. Has ever had a seizure, or has a family history of epilepsy 2. Taking medications or substances that lower the seizure threshold 3. Implanted devices that are…
Interventions
- BehavioralRealtime fMRI Neurofeedback - Active
fMRI aided reinforcement of craving regulation
- DeviceTMS - Active
rTMS to right dorsolateral prefrontal cortex to reduce craving
- BehavioralRealtime fMRI Neurofeedback - Yoked Sham
Display of feedback from other participant's sessions to serve as a sham for fMRI aided reinforcement of craving regulation
- DeviceTMS - Sham
rTMS using placebo coil (no brain stimulation, emulates other features of active TMS), placed over right dorsolateral prefrontal cortex
Location
- Auburn UniversityAuburn, Alabama