Endeavor Health
The goal of this clinical trial is to determine the best combination of drugs and drug delivery routes to treat surgically naive chronic rhinitis patients. The main question it aims to answer is: Do high volume, high pressure delivery mechanisms in nasal irrigation improve the efficacy of azelastine combined with nasal steroid mometasone as compared to the standard low pressure, low volume delivery mechanisms in nasal sprays? Subjects will complete six months of one of three medication regimens: 1. Saline irrigation followed by azelastine spray and mometasone spray 2. Mometasone saline irrigation 3. Azelastine saline irrigation combined with mometasone saline irrigation.
The purpose of this research is to determine whether patients with chronic rhinitis treated with mometasone and azelastine irrigations will show significant clinical improvement when compared to patients treated with mometasone and azelastine nasal sprays, and also compared to nasal irrigation with mometasone alone. Patients with chronic rhinitis require lifelong treatment options that are safe yet efficacious. Topical therapies, such as antihistamine sprays and steroid sprays as well as saline irrigations, are appropriate options as they offer symptom control without the side effects often se…
Inclusion Criteria: * Adults 18 years and older seeking treatment for chronic rhinitis and willing to undergo six months of topical therapy. * Diagnosis of Chronic Rhinitis. Exclusion Criteria: * The patient has diagnosis(es) other than chronic rhinitis that can account for his/her symptoms (septal deviation, nasal valve collapse, chronic sinusitis). * Use of oral antihistamines or oral steroids, unless patient undergoes a 4 week washout period. * Smokers (tobacco, marijuana, vaping, etc.). * Known or suspected pregnancy, or lactation. * Other medical conditions that the investigator believ…
Participants will follow this medication regimen for 6 months.
Participants will follow this medication regimen for 6 months.
Participants will follow this medication regimen for 6 months.
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