Effect of Non-steroidal Anti-inflammatory Drugs on Serum Prostate Specific Antigen Level
Albany Medical College
Summary
Prostate cancer is the most frequently diagnosed cancer in men in the Unites States. Nearly 1 million prostate biopsy procedures are performed in the United States annually and elevated prostate-specific antigen (PSA) level is the primary reason for prostate biopsy in \> 90% of cases. However, at the PSA levels which trigger prostate biopsy, often no cancer is found in prostate biopsy specimens. PSA test can be elevated due to reasons other than cancer such as inflammation or natural variation in the level. Investigators plan to treat men with elevated PSA level with over the counter anti-inflammatory medications (ibuprofen, naproxen) to see if the PSA level will decrease to an acceptable level.
Description
It's known that PSA level can be elevated due to reasons other than prostate cancer including benign prostatic hypertrophy, prostatitis or other urinary tract infections, non-infectious inflammation, and physiologic variation over time. Consequently, nearly 50% of prostate biopsy procedures performed due to elevated PSA level do not yield any cancer , but still expose the patients to the risks of the procedure related complications (discomfort/pain, anxiety, bleeding, infection, and cost). Thus, measures to improve the reliability of PSA test, and potentially avoiding unnecessary procedures, a…
Eligibility
- Age range
- 18–80 years
- Sex
- Male
- Healthy volunteers
- No
Inclusion Criteria: * Male patients age between 18-80 years old with a screening PSA \> 3 ng/ml being considered for additional diagnostic testing (e.g., MRI, biopsy) * Normal digital rectal examination within the past two years. A documented normal digital rectal examination by another physician or advanced practice provider (NP, PA, etc) is acceptable. * No clinical symptoms concerning for acute urinary tract infection (e.g. dysuria, malodorous urine, positive urine culture) Exclusion Criteria: * History of hypersensitivity or allergy to ibuprofen or NSAIDs. * History of peptic ulcer dise…
Interventions
- DrugIbuprofen 400 mg, TID
Participants will receive Ibuprofen 400 mg 3 times per day for 10 days.
- Diagnostic TestPSA test
PSA test will be repeated in 6 weeks
Locations (3)
- University of Chicago Medical CenterChicago, Illinois
- Albany Medical CenterAlbany, New York
- Penn State-Hershey Medical CenterHershey, Pennsylvania