Multimodal Magnetoencephalography and Electroencephalography Exploration of the Acute Effects of THC Exposure on Neural Noise and Information Transmission Within Working Memory Networks
Yale University
Summary
The purpose of this study is to use non-invasive brain imaging methods (MEG and EEG) to characterize the effects of THC on brain activity during learning.
Description
The goal of this study is to use multimodal MEG/EEG to gain novel insight into the acute effects of THC on neural noise and its interaction with the fast information processing dynamics of the brain's cognition-related functional neural networks.
Eligibility
- Age range
- 21–65 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Cannabis use at least once in the past 12 months * No cannabis use during the course of the study confirmed with negative urine toxicology at screening and on each test day * Good physical and mental health Exclusion Criteria: * Cannabis naïve individuals * Lifetime or current medical, psychiatric or psychosocial disorders or history that is deemed unsuitable for participation in the study per PI discretion. * Positive pregnancy test, lactation, or refusal to practice birth control for the duration of the study and for two weeks following completion * Major current or…
Interventions
- DrugTHC
Participants will receive THC into a rapidly flowing IV infusion.
- OtherPlacebo
Participants will receive an equivalent amount (about 1-2 ml) of placebo (sterile 190 proof USP ethanol). The placebo does not produce any measurable blood alcohol levels or subjective/behavioral effects.
Location
- VA Connecticut Healthcare System, Yale School of MedicineWest Haven, Connecticut