Autonomic Effects of Transcutaneous Spinal Cord Stimulation in Veterans With SCI
VA Office of Research and Development
Summary
This study aims to determine the effects of transcutaneous spinal cord stimulation to increase blood pressure and use that device to increase power output and heart rate recovery during arm cycle ergometry. In addition, the investigators will see if the stimulation helps regulate body temperature when in a cool environment.
Description
This study aims to determine the effects of transcutaneous spinal cord stimulation to increase blood pressure and use that device to increase exercise power output and heart rate recovery during arm cycle ergometry. In addition, the investigators will see if the stimulation helps regulate body temperature when in a cool environment. Study 1 (arm cycle ergometry) will consist of 2 visits that will be between 2-3 hours in duration, separated by no less than 3 days, and will consist of putting the electrode at the optimal spot on the spine and completing a submaximal arm ergometry exercise and th…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * injury more than 1 year ago, non-ambulatory * level of lesion C3-T6, AIS A, B, or C * stable prescription medication regimen for at least 30 days * must be able to commit to study requirements of 7 visits within a 60-day period Exclusion Criteria: * extensive history of seizures * ventilator dependence or patent tracheostomy site * history of neurologic disorder other than SCI * history of moderate or severe head trauma * contraindications to spine stimulation * significant cardiovascular disease * active psychological disorder * recent history (within 3 months) of sub…
Interventions
- DeviceDS8R
transcutaneous stimulation of the spinal cord.
- OtherArm Ergometry
Study 1 will use the arm ergometry as a form of exercise.
- OtherCool Environment
Study 2 will be completed in a cool environment setting.
Location
- James J. Peters VA Medical Center, Bronx, NYThe Bronx, New York