Pilot Study of Transcranial Direct Current Stimulation (tDCS) to Treat Epilepsy
Mayo Clinic
Summary
The purpose of this research is to see to what extent electrical stimulation applied to the scalp (transcranial direct current stimulation or tDCS) can reduce the number and intensity of epileptic seizures.
Description
tDCS for treatment of epilepsy has been studied previously with results suggesting that it can lead to a notable seizure reduction for a limited time period after the cessation of stimulation, e.g., about one month. Here, we assess further aspects of tDCS treatment protocols, including the feasibility and safety of at-home use.
Eligibility
- Age range
- 6+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria * Clinical diagnosis of generalized onset or focal epilepsy or sleep-related epileptic encephalopathy. * Estimated to have at least 2 countable seizures per month or spike-wave index ≥50%. * Has not had control with at least 2 anti-seizure medicines. * Able to maintain a constant medication for duration of the study (rescue meds allowed). * Subject or legally authorized representative is able to understand consent and keep a seizure diary in English. Exclusion Criteria: * A disease likely to progress over course of the study. * Psychogenic non-epileptic seizures. * Suicid…
Interventions
- DeviceActivaDose II 0.1 mA transcranial direct current stimulation (tDCS)
Stimulation setting 0.1 mA daily for a 2-month period. Each daily treatment will last for approximately 30 minutes.
- DeviceActivaDose II 2.0 mA transcranial direct current stimulation (tDCS)
Stimulation setting 2.0 mA daily for a 2-month period. A Each daily treatment will last for approximately 30 minutes.
Location
- Mayo Clinic MinnesotaRochester, Minnesota