Chronic Health Conditions in Down Syndrome-Associated Acute Leukemia: The Down Syndrome Phenotyping Acute Leukemia Study in Survivors (DS-PALS Survivors)

Summary

This study attempts to learn more about the health of persons with Down syndrome after treatment for acute leukemia. Children with Down syndrome are at increased risk for side effects during treatment for acute leukemia, but it is unclear of their risk for long-term effects of cancer treatment. By learning more about the factors that may contribute to chronic health conditions and long-term effects after treatment for leukemia in persons with Down syndrome, clinical practice guidelines for survivorship care can be developed to help improve their quality-of-life.

Description

Eligibility

Age range

6–39 years

Sex

All

Healthy volunteers

No

Interventions

• Procedure
  Biospecimen Collection

  Patients undergo saliva/buccal and blood sample collection

• Other
  Clinical Evaluation

  Undergo a clinical assessment

• Other
  Neurocognitive Assessment

  Undergo neurocognitive assessment

• Other
  Questionnaire Administration

  Ancillary studies

• Other
  Survey Administration

  Ancillary studies

Locations (70)