Using Indoor Air Filtration to Reduce PM2.5 Cardiometabolic Effects in At-risk Individuals
University of Southern California
Summary
The goal of this randomized, double-blind, crossover trial is to test the hypothesis that a longer-term indoor HEPA filtration intervention can improve cardiometabolic profiles by reducing indoor PM2.5 exposures in at-risk individuals.
Description
This randomized, double-blind, crossover trial will recruit 52 non-diabetic adults and will investigate potential benefits of HEPA air purifiers on improving cardiometabolic profiles. Participants will be contacted and recruited to the study based on inclusion and exclusion criteria. After consenting, participants will be block randomized to HEPA and control groups for 6-month interventions by sex. After 6-month wash-out period, participants will be switched to the other arm of the intervention. During the trial, project specialists will complete a series of home visits before and after each i…
Eligibility
- Age range
- 65–84 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Age between 65 and 84 years old; * Nonsmoker for at least 1 year; * History of BMI ≥ 25 kg/m2 in the past based on EMR information; * Either an English or Spanish speaker; * Live in the Los Angeles County. Exclusion Criteria: * History of diabetes (both type 1 and type 2) or degenerative disease of the nervous system (Alzheimer's disease or dementia); * Currently have active cancer treatment; * The residential house has already had HEPA filters; * Participants will move out of the current house in the next 2 years; * Participants will spend more than one month living o…
Interventions
- DeviceHEPA filter
HEPA filters with the capacity to reduce PM2.5 levels
- DeviceSham filter
sham filters without the capacity to reduce PM2.5 levels
Location
- Keck School of Medicine, University of Southern CaliforniaLos Angeles, California