First-in-Human, Phase 1 Study of AMT-116 in Patients With Advanced Solid Tumors
Multitude Therapeutics Inc.
Summary
This first-in-human study will evaluate the Maximum Tolerated Dose (MTD) / the Recommended Phase 2 Dose (RP2D), safety, tolerability, anti-tumor activity, pharmacokinetics, pharmacodynamics and immunogenicity of AMT-116, in Patients with Advanced Solid Tumors
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Key Inclusion Criteria: * Patients must be willing and able to sign the ICF, and to adhere to the study visit schedule and other protocol requirements. * Age ≥18 years (at the time consent is obtained). * Patients with histologically confirmed, unresectable advanced solid tumor. Preferred tumor types include head and neck, non-small cell lung, esophageal, pancreatic, large cell lung, colorectal, cervical, breast, bladder, gastric, biliary tract, skin squamous cell, liver, and basal cell cancer. * Patients who have undergone at least one systemic therapy and have radiologically or clinically d…
Interventions
- DrugAMT-116
Administered intravenously
Locations (10)
- Sarah Cannon Research InstituteDenver, Colorado
- Mary Crowley Cancer Research CentersDallas, Texas
- University of California San Francisco Cancer CenterSan Francisco, California
- Carolina BioOncology Institute, LLCCary, North Carolina
- Macquarie University HospitalSydney, New South Wales
- ICON Cancer CentreBrisbane, Queensland