Effects of the Contraceptive Implant in Women With Sickle Cell Disease
University of Pennsylvania
Summary
The objective of this study is to measure the acceptability and impact of the progestin implant on frequency of vaso-occlusive crises, quality of life, and hematologic parameters in women with SCD.
Description
Sickle cell disease (SCD) is the most common inherited blood disorder in the United States, affecting 100,000 primarily Black people. The disease is characterized by chronic pain and infection, and ultimately reduces life expectancy by 20 years compared to people without SCD. Given the importance of effective contraception for women with sickle cell disease, as well as previously demonstrated therapeutic benefits of hormonal contraception, the etonogestrel implant may be an optimal method of contraception for women with SCD. This study aims to measure the acceptability and impact of the proge…
Eligibility
- Age range
- 18–45 years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Female aged 18-45 * Diagnosis of sickle cell disease (SS or SB0) * Report of at least 1 vaso-occlusive pain episode per month on average in the previous 6 months * Willing to discontinue any hormonal contraception at the time of enrollment. Washout period of 1 month required for all hormonal contraception prior to enrollment in the study. * Access to a device with text messaging capability * Must be able to read and understand English * Willing to comply with study procedures Exclusion Criteria: * SC Disease * Use of Depo Provera in the past 6 months * Changes to sickl…
Interventions
- DrugNexplanon 68 MG Drug Implant
Progestin contraceptive device
Location
- Penn Medicine University CityPhiladelphia, Pennsylvania