Effect of CPAP on 24-Hour Blood Pressure in the Excessively Sleepy Obstructive Sleep Apnea Subtype
Ohio State University
Summary
The primary objective of this study is to determine the longer-term (6 months) effect of CPAP therapy on change in 24-hour mean blood pressure (24hMBP) in OSA subjects with the excessively sleepy symptom subtype.
Description
This is a prospective, non-randomized, observational, two-center study involving newly diagnosed subjects with moderate-severe OSA with the excessively sleepy symptom subtype. Variables of Interest: Change in 24-hour ambulatory BP, change in sitting BP, change in reaction time by psychomotor vigilance test (PVT) Participants will complete questionnaires that pertain to demographics, lifestyle factors, and co-morbidities. The blood samples will be used to determine levels of BP medications and serum creatinine. Measurements will be collected at baseline and at 6-month follow-up visits. Data…
Eligibility
- Age range
- 18–75 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Age 18-75 years * Moderate-severe OSA (defined as ODI ≥10 events/hour) via Polysomnography (PSG) or Home Sleep Apnea Study (HSAT) done based on clinical grounds * Excessively sleepy subtype determined by patient-reported symptoms * Willing to accept CPAP therapy * An elevated baseline office BP defined as ≥120 or ≥80 mmHg * Planned PAP (CPAP or bi-level PAP) treatment by treating provider Exclusion Criteria: * Recent changes (within 3 months) to BP medications among those who are on these medications * Unable to apply ABPM cuff * Current use of CPAP or other OSA treatm…
Interventions
- DeviceCPAP therapy
CPAP treatment of obstructive sleep apnea with the excessively sleepy symptom subtype
Locations (2)
- The Ohio State University - Martha Morehouse Medical Pavilion, Suite 2600Columbus, Ohio
- University of PennsylvaniaPhiladelphia, Pennsylvania