Home Sleep Therapy System for Mild Cognitive Impairment
Brain Electrophysiology Laboratory Company
Summary
The goal of this clinical trial is to learn about the ability of non-invasive brain stimulation during sleep to enhance people's deep sleep and its potential benefit on memory in people with mild cognitive impairment via home use sleep therapy device (SleepWISP) as well as learn about biomarkers associated with Alzheimer disease (AD). The clinical trial aims to answer the following main questions: 1. Whether the non-invasive transcranial electrical stimulation (TES) delivered by SleepWISP could provide short-term enhancement of deep sleep in a single night in the target population. 2. Whether TES delivered by SleepWISP could enhance deep sleep over multiple nights in the target population. 3. Whether enhance on deep sleep could improve memory performance in the target population. Participants will be asked to wear non-invasive and painless devices that record their brain activity during sleep along with an actigraphy watch that measures their movement throughout the day. In addition, blood samples or nasal swab assays will be collected from participants multiple times during the study.
Description
The purpose of the present research is to evaluate the ability of non-invasive transcranial electrical stimulation (TES) during slow-wave sleep (SWS) to enhance this stage of sleep for people with mild cognitive impairment (MCI). A previous study of the investigators have demonstrated, in a pilot study, that TES can acutely (i.e., immediately after TES) increase SWS duration in healthy people. In the present proposal, the investigators aim to replicate and extend the pilot findings in seniors with MCI. It is evidenced that decline in SWS duration with aging is associated for memory impairment…
Eligibility
- Age range
- 40–85 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * For participant with Amnestic MCI, the inclusion age range is 55-85 years old. * For healthy volunteers without MCI, the inclusion age range is 40-80 years old. Exclusion Criteria: * History of seizures * History of epilepsy * History of mod/severe brain injury or trauma (including neurosurgery) * History or presence of significant neurological disease such as Parkinson * History of Electroconvulsive Therapy (ECT) * Presence of severe insomnia * Presence of untreated sleep apnea * Presence of severe anxiety or depression * Medications that may affect the EEG * History…
Interventions
- DeviceTranscranial Electrical Stimulation
Oscillating electrical current
Locations (2)
- Wake Forest UniversityWinston-Salem, North Carolina
- Brain Electrophysiology Laboratory CompanyEugene, Oregon