Ovarian Platelet-Rich Plasma Injections for Diminished Ovarian Reserve Patients: A Double-Blinded Placebo-Control Trial
Generation Next Fertility
Summary
This prospective double-blinded randomized placebo control study aims to determine if In Vitro Fertilization (IVF) outcomes are improved by ovarian platelet-rich plasma injections (oPRP) for women diagnosed with diminished ovarian reserve (DOR). Women with DOR notoriously have the lowest chance of pregnancy and live birth compared to age-matched peers with a normal or robust ovarian reserve.
Description
A randomized, double-blind, placebo-controlled trial comparing ovarian injection of platelet-rich plasma vs. placebo in women diagnosed with diminished ovarian reserve at risk for a poor ovarian response (POR) between 35 to 42 years of age. Participants for this study include patients who are planning to undergo IVF with preimplantation genetic testing for aneuploidy (PGT-A) followed by a frozen embryo transfer (FET) cycle. Only patients with either a euploid embryo or eligible mosaic embryo (following consultation with a geneticist), as determined by PGT-A, will be allowed to proceed with a s…
Eligibility
- Age range
- 35–42 years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: * Clinical diagnosis of diminished ovarian reserve * Clinical diagnosis of poor ovarian response * Women age 35-42 Exclusion Criteria: * Clinical diagnosis of premature ovarian failure * Clinical diagnosis of menopause. * Under 35 years of age * Over 42 years of age
Interventions
- OtheroPRP
Prepared sample from patient's own blood collected and processed. Either PRP or serum is injected into the patient's ovary. All other care is standard for the IVF process
- OtherPlacebo- Serum
Patient's serum is injected into ovary instead of PRP as placebo
Location
- Generation Next FertilityNew York, New York