An Open-label, Multicenter, Phase 1 Study Evaluating the Safety, Pharmacokinetics, and Efficacy of BA3182, a Bispecific Epithelial Cell Adhesion Molecule (EpCAM)/CD3 Antibody, in Patients With Advanced Adenocarcinoma
BioAtla, Inc.
Summary
The objective of this study is to assess safety and efficacy of BA3182 in Advanced Adenocarcinoma
Description
This is a multi-center, open-label, Phase 1 study designed to evaluate the safety, tolerability, PK, immunogenicity, and antitumor activity of BA3182 in patients with advanced adenocarcinoma.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Histologically or cytologically confirmed locally advanced unresectable or metastatic adenocarcinoma * Age ≥ 18 years * Adequate renal function * Adequate liver function * Adequate hematological function * Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. Exclusion Criteria: * Patients must not have clinically significant cardiac disease. * Patients must not have known non-controlled CNS metastasis. * Patients must not have active autoimmune disease or a documented history of autoimmune disease. * Patients must not have a history of ≥ Grad…
Interventions
- DrugBA3182
Conditionally active biologic (CAB)-bispecific T-cell engager antibody construct targeting EpCAM
Locations (9)
- UC IrvineIrvine, California
- USC Norris Comprehensive Cancer CenterLos Angeles, California
- Yale Cancer CenterNew Haven, Connecticut
- Northwestern UniversityChicago, Illinois
- University of IllinoisChicago, Illinois
- Karmanos Cancer InstituteDetroit, Michigan