Treatment of Orthostatic Hypotension in Individuals With Spinal Cord Injury
James J. Peters Veterans Affairs Medical Center
Summary
The purpose of this study is to identify the effects of non-pharmacological and pharmacological anti-hypotensive treatment interventions on orthostatic hemodynamic responses, symptoms of autonomic dysreflexia and orthostatic hypotension, and levels of fatigue and comfort in hypotensive individuals with SCI.
Eligibility
- Age range
- 18–60 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * traumatic spinal cord injury * at least 12 months post injury * injury level of C1-T6 * AIS A, B or C * non-ambulatory * non-ventilator Exclusion Criteria: * Active psychiatric disorder * Stroke or cerebrovascular disease * Alzheimer's Disease or dementia * Unmanaged cardiac arrhythmias * Concurrent systemic, hepatic, or renal disease * Suspected or diagnosed malignancy * Neurological disease other than SCI * Self-reported history of three or more symptomatic episodes of AD per day
Interventions
- DrugMidodrine Hydrochloride
Determine best drug and dose to increase and stabilize SBP during orthostatic tilt
Locations (2)
- Kessler FoundationWest Orange, New Jersey
- James J Peters VA Medical CenterThe Bronx, New York