University of Nevada, Las Vegas
The purpose of this study is to explore the relationships of exercise on inflammation in the body of older adults and people with Parkinson's disease (PD). This is important research for older adults but is especially important for people with PD because neuroinflammation is the main pathological mechanism that is responsible for neuron cell death in this neurodegenerative disease. As PD is a progressive disease, halting or slowing the degeneration is an important research target. Halting or slowing the disease progress is known as neuroprotection. Exercise is an attractive therapeutic treatment for people with PD as it has a lot of multi-systemic benefits, but also there is a lot of evidence to suggest that it helps improve symptoms and slow the progression of the disease. Exercise has been theorized to decrease inflammation and, therefore, has a lot of promise as a neuroprotective agent in slowing or halting the degeneration in PD. Unfortunately, there is not a lot of research that has looked into the effect of exercise on the biological processes of inflammation. Thus, the purpose of this study is to investigate the biological evidence that underlies the positive effect of exercise in people with PD.
Parkinson's disease (PD) is the second most common neurodegenerative disease, affecting an estimated 4 million individuals and 1% of those over the age of 60. The pathologic hallmark of PD are Lewy bodies in neurons and these inclusion bodies are largely made up of misfolded α-synuclein. These α-synuclein inclusion bodies cause mitochondrial respiratory dysfunction which results in reactive oxygen species causing oxidative stress; this, in turn, leads to more aggregation of α-synuclein and a vicious cycle ensues. Ultimately, this vicious cycle results in dopaminergic neuron cell death causing…
Inclusion criteria for PwP: * 30-85 years old * Neurologist-diagnosed PD * Able to participate in 30 minutes of continuous moderate aerobic exercise with 2-3 short breaks per self-report. Inclusion criteria for controls: * 30-85 years old * No major medical diagnoses * Able to participate in 30 minutes of continuous moderate aerobic exercise with 2-3 short breaks per self-report. Exclusion Criteria for both PD group and controls: * Diagnoses, identified by self-report, that would preclude exercise participation (e.g., heart arrhythmias, uncontrolled blood pressure, exercise-induced asthma…
The intervention is exercise and there are no drugs or devices used in this trial. The exercise consists of two intensity levels of a 30-minute aerobic exercise intervention with both arms crossing over to both conditions: low intensity exercise (60-70% of estimated maximum heart rate (EMRH)) and moderate-vigorous intensity exercise (75-85% of EMHR).
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