Slowing Atherothrombosis Progression Through Indoor Air Filtration: A Crossover Trial in Hispanic and Non-Hispanic Adults With Ischemic Heart Disease History
University of Southern California
Summary
This double-blind, randomized, crossover trial aims to test the hypothesis that longer-term indoor air filtration intervention can slow atherothrombosis progression by reducing indoor fine particulate matter (PM2.5) exposure in adults with ischemic heart disease history.
Description
This double-blind, randomized, crossover trial will recruit 112 adults with ischemic heart disease history and will investigate potential benefits of indoor high efficiency particulate air (HEPA) filtration on ameliorating the progression of atherothrombosis. Participants will be contacted and recruited to the study based on inclusion and exclusion criteria. After consenting, participants will go through a total of 21-month study period comprised of true HEPA filtration and sham filtration, each of 9-month in duration, and a 3-month wash-out period. After 3-month wash-out period, participants…
Eligibility
- Age range
- 65–84 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Age between 65 and 84 years old; * Weight ≥ 110 pounds; * Nonsmokers for at least 1 year; * Have ischemic heart disease history, clinically stable for 6 months, without any deterioration in symptoms or episodes of angina based on past electronic medical records; * Both English and Spanish speaking participants will be included in the recruitment; * Live in the Los Angeles County. Exclusion Criteria: * Have history of degenerative disease of the nervous system such as dementia and Alzheimer's; * Currently have active cancer treatments; * The residential house has alread…
Interventions
- DeviceHEPA filtration
HEPA filters with the capacity to reduce PM2.5 levels
- DeviceSham filtration
Sham filtration use the same appearance of air purifier but with HEPA filter removed.
Location
- Keck School of Medicine, University of Southern CaliforniaLos Angeles, California