iMmune SignAtures and Clinical outComes in Acute Pancreatitis: the MoSAIC Study
Ohio State University
Summary
The MoSAIC study is a prospective, observational study designed to develop an early prediction tool for severe acute pancreatitis (SAP) and define a distinct immunologic profile compared to moderate acute pancreatitis (MAP). The aims are to validate a new multi-cytokine panel for early prediction of SAP and to identify the specific immune cells that correspond with cytokine signatures in early acute pancreatitis to characterize the immune pathways driving the development of SAP. Participants will provide blood samples and complete patient surveys and interviews within 36 hours of hospital presentation, at 48 hours, and hospital day 7 (if admitted). Data on hospital stay, medical history, clinical course, and severity of disease will be collected.
Description
All participants will sign an informed consent before participating in the study. Adult subjects of both sexes and belonging to all ethnicities will be enrolled. Participants will consent for access to their electronic health records, complete study questionnaires, undergo serial clinical laboratory testing and provide biospecimens during their acute pancreatitis (AP) hospitalization. The research team will access the electronic health records for 5 years from the time of enrollment in the study. The study network is comprised of five academic sites. Four sites will enroll AP patients \[OSU,…
Eligibility
- Age range
- 18–75 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Age 18-75 years at the time of enrollment 2. Diagnosis of acute pancreatitis (AP) according to the revised Atlanta criteria (see definition below) 3. Participant is approached by the research team within 36 hours of presentation to the hospital 4. Participant fully understands and agrees to participate in all aspects of the study, including providing informed consent, completion of interviews and data forms, and collection of biospecimens Acute pancreatitis is defined/diagnosed using the revised Atlanta criteria, which requires the presence of at least two of the follo…
Interventions
- Diagnostic TestCyTOF Analysis
CyTOF laboratory testing for cytokine levels to correlate with severity of acute pancreatitis
Locations (5)
- University of Southern CaliforniaLos Angeles, California
- University of Illinois ChicagoChicago, Illinois
- The Ohio State UniversityColumbus, Ohio
- University of PittsburghPittsburgh, Pennsylvania
- Benaroya Research InstituteSeattle, Washington