Immune Function and the Progression to Type 1 Diabetes:
University of Florida
Summary
To elucidate the mechanisms by which type 1 diabetes-associated genes; IFIH1, TYK2, IKZF4, as well as total genetic risk, impart functional immunoregulatory abnormalities that result in expansion of self-reactive adaptive immune cells, defective regulatory/effector mechanisms in T cells, inflammatory antigen presenting cells, and abnormal immune function in T cells and B cells.
Description
Newly proposed studies will identify the inflammatory cues that draw immune cells into islets for disease initiation (Project 1); probe the motility of immune cells through inflamed vasculature to the target organ and antigen priming sites within secondary lymphatics (Project 2); and characterize the T1D-associated adaptive immune signatures in blood and immune tissues (Project 3). The overall hypothesis of the renewed P01 states: 1) the impact of T1D-risk variants will vary by tissue, cell subset, and activation state, and 2) risk variants, cellular stress, and defects in immunologic pathway…
Eligibility
- Age range
- 0–100 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: able to have blood drawn - Exclusion Criteria: none \-
Interventions
- Otherblood draw
a peripheral blood draw
Locations (3)
- Kieran McGrailGainesville, Florida
- The Ohio State UniversityColumbus, Ohio
- Baylor College of Medicine, Center for Research Advancement - Texas Children's HospitalHouston, Texas