Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease
Massachusetts General Hospital
Summary
The project is a placebo-controlled study that aims to use closed-loop transcranial alternating current stimulation (tACS) to study patients with symptoms of mild cognitive impairment which is likely due to Alzheimer's disease or another form of dementia (AD-MCI). Patients will undergo an EEG and complete some questionnaires and computer tasks during each study visit. The project has the following aims and hypotheses: 1.) To determine the impact of closed-loop 40 Hz tACS on the entrainment of natural gamma rhythms in patients with AD-MCI, 2.) To determine the impact of closed-loop 40 Hz tACS on cognitive performance in patients with AD-MCI, and 3.) To assess the relationship between baseline neurodegenerative burden and impact of tACS. \[exploratory\]
Eligibility
- Age range
- 50–80 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Overall cognitive functional status consistent with amnesic MCI (CDR 0.5) likely due to AD (AD biomarker supported) * 50-80 years of age * English native speakers Exclusion Criteria: * Known presence of a structural brain lesion (e.g., tumor, cortical infarct) * Acute or decompensated active medical conditions, including cancer, cardiovascular disease, stroke, congestive heart failure * Active hematological, renal, pulmonary, endocrine or hepatic disorders * Longstanding premorbid history (i.e., longer than 10 years) of alcohol or substance abuse with continuous abuse…
Interventions
- DevicetACS device
you will receive one of four treatment conditions that include active and sham tACS. The four conditions are the following: (1) closed-loop-tACS (peak-locked), (2) closed-loop-tACS (trough-locked), (3) open-loop tACS, and (4) sham tACS. Although each subject will undergo all four treatments in four separate study visits, the order of the treatments will be randomized
Location
- Massachusetts General HospitalCharlestown, Massachusetts