Randomized Controlled Trial of Ultra-Low Contrast Coronary Angiography During Acute Kidney Injury (AKI)
Tulane University
Summary
The aim of this study is to evaluate the safety of ultra-low contrast coronary angiography in patients with pre-existing acute kidney injury.
Description
The study is a non-inferiority open-label randomized controlled trial. Hospitalized patients who have AKI at admission or who develop AKI during admission and require invasive coronary angiography will be included in the trial. Once indication for invasive coronary angiography is determined, patients will be randomized to immediate angiography or to delayed angiography after renal function stabilizes. Immediate angiography will be performed within 24 of enrollment. Serum creatinine will be collected on enrollment, within 6 hours before coronary angiography, and at 24h, 48h and 1-week after the…
Eligibility
- Age range
- 18–100 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Hospitalized patients who have AKI at admission or who develop AKI during admission and require invasive coronary angiography will be included in the trial. Exclusion Criteria: * Stabilized renal function manifested by unchanged or downtrending serum creatinine during a 24-hour period prior to enrollment. * Contraindication for invasive coronary angiography other than AKI. * Percutaneous coronary intervention is indicated and cannot be postponed by 7 days. * Need for renal replacement therapy before coronary angiography or planned renal replacement therapy after corona…
Interventions
- ProcedureAngiography
Coronary angiography with less than 20cc of contrast materials
Locations (2)
- Tulane University Medical CenterNew Orleans, Louisiana
- University Medical CenterNew Orleans, Louisiana