University of New Hampshire
This clinical trial aims to learn about the alterations in insulin resistance and metabolic flexibility following a transition to an obesogenic lifestyle in fit young men and women. The main questions it aims to answer are: 1. Does adding excess carbohydrates when transitioning to a sedentary lifestyle promote insulin resistance and impaired 24hr glucose regulation in healthy men and women? 2. Does adding excess carbohydrates when transitioning to a sedentary lifestyle lower the body's ability to break down fats and carbohydrates in healthy men and women? 3. Does the added physical activity blunt shifts in carbohydrate and fat oxidation in healthy men and women?
Excess adiposity remains a critical health issue in the United States. Obesity and severe obesity are projected to reach approximately 34% and 9% by 2030, respectively. However, recent 2021 NHANES data reveals that our obesity and severe obesity population has already surpassed these estimates reaching 41.9% and 9.2% by 2022, respectively. While early childhood obesity has a prevalence of about 22%, which can lead to obesity during adulthood, young adulthood (20-39 years old) is another critical time where young adults without obesity or severe obesity will accumulate excess adiposity as part…
Inclusion Criteria: * 18-30 years of age * Recreationally active completing 75-150 minutes of moderate-to-vigorous intensity exercise (\>2 days/week). * Fair cardiorespiratory fitness levels (Men: VO2\>38.4 ml/kg/min; Women: VO2\>32.6 ml/kg/min). Exclusion Criteria: * Hypertension (resting or diagnosed) * Impaired fasting blood glucose (\>100mg/dL) * Diagnosed cardiovascular disease * Diagnosed diabetes * Diagnosed cancer * Diagnosed chronic kidney disease * Diagnosed musculoskeletal disorders that prevents the individual from exercising on a bike.
Young men and women will transition into a low physically active lifestyle for 10 days and consume added sugar-sweetened beverages. The intervention group will be compared to two control groups and one experimental group. One of the control groups will undergo a low physical activity intervention.
Young men and women will transition into a low physically active lifestyle for 10 days.
Young men and women will transition into a high physically active lifestyle for 10 days and consume added sugar-sweetened beverages. The intervention group will be compared to two control groups and one experimental group.
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