An Observational Post-Intervention Control Destination Cohort
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Summary
This study is being done to see if people who control HIV without antiretroviral therapy (ART) after receiving an intervention can remain off ART safely. The information collected in this study is also being used to try to understand how people control HIV without ART after receiving an intervention.
Description
This study is a two-step non-interventional study for participants who achieved prolonged viral control off ART, post-intervention (post-intervention control \[PIC\]) in qualifying AIDS Clinical Trials Group (ACTG) and non-ACTG interventional cure trials (parent studies).
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Step 1 Inclusion Criteria: * Currently or previously enrolled in a qualifying ACTG or non- ACTG parent study of curative or suppressive HIV therapy that included an ATI. * If feasible, participants should not remain co-enrolled in their respective parent study after entering A5385. * Achieved at least 24 weeks of HIV virus suppression (as defined by the parent study) following ATI initiation, remains off ART with \<4 consecutive weeks of HIV-1 RNA \>1000 copies/mL, CD4+ T-cell count \> 350 cells/mm3 and not experiencing symptoms of acute retroviral syndrome. NOTE: Participants whose particip…
Locations (4)
- University of California, San Francisco HIV/AIDS CRS (801)San Francisco, California
- Washington University Therapeutics (WT) CRS (2101)St Louis, Missouri
- Weill Cornell Upton CRS (7803)New York, New York
- Case CRS (2501)Cleveland, Ohio