Vanderbilt-Ingram Cancer Center
This study will apply novel MRI approaches with established sensitivity to tissue oxygen consumption and perfusion to predict hypoxia-associated radiation resistance, manifested as tumor recurrence and progression post-treatment.
Primary Objective: \- To validate non-invasive, MRI-based markers of tumor hypoxia in patients with brain metastases or head and neck cancer with and without evidence of tumor hypoxia identified by 18F-FMISO-PET-CT. Secondary Objectives: * To assess treatment-related changes in tumor and peritumoral tissue oxygen consumption and perfusion via non-invasive MRI. * To evaluate the effect of pre-treatment and post-treatment (3 months) tumor hypoxia on tumor recurrence, progression, and radiation necrosis in patients with central nervous system metastases treated with standard of care stereotact…
Inclusion Criteria: * Histologically or cytologically confirmed head and neck squamous cell carcinoma or a clinical diagnosis of CNS-excluded nervous system neoplasm and disorder (brain metastases) * Measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded for non-nodal lesions and short axis for nodal lesions, minimum size 7mm) with CT scan, MRI, or calipers by clinical exam * ECOG performance status \</=1 Karnofsky \>/=70% * Life expectancy of greater than 6 months * The effects of 18F-FMISO on the developi…
Participants will undergo Magnetic Resonance Imaging
Participants will undergo Positron Emission Tomography
Given by IV
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