PLANET: Exploring the Role of Plastics and Toxins in Intestinal Inflammation
Icahn School of Medicine at Mount Sinai
Summary
The PLANET Study aims to determine the impact of microplastics on intestinal inflammation and gut microbiome in order to understand the role of this pollutant on the risk of developing inflammatory bowel disease (IBD) as well as other diseases. With this information, the researchers hope to characterize better the role of environmental pollutants on IBD and develop novel strategies towards prevention.
Description
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a chronic, progressive inflammatory disease of the intestinal tract. The etiology of IBD is not well understood, but believed to result from a complex relationship between genetics, environment, and gut microbiome alterations, resulting in a self-perpetuating, abnormal mucosal immune response. The incidence of IBD is rising in developing and recently developed countries, highlighting the importance of environmental exposures in determining disease risk. Microplastics, defined as plastic particles \…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * The ability to sign and date an informed consent form * Be pregnant, or wishing to become pregnant in the near future and enroll the infant that the individual is pregnant with * Aged 18 or older * English-speaking (this observational study uses non-validated questionnaires that are only available in English) * Of any ethnicity * Be a spouse, related household member (sibling, parent, etc.) or a child of an enrolled pregnant person Exclusion Criteria: * Individuals who are unable to give informed consent * Be diagnosed with a pregnancy complication, such as intrauterin…
Location
- Icahn School of Medicine at Mount SinaiNew York, New York