Relationship Between Sex Hormones, Postoperative Pain and Opioid Use: the Role of Immune Factors
Washington University School of Medicine
Summary
Aim 1- To identify relationships between sex hormone levels and postoperative pain and opioid use. Aim 2: To determine whether the effects of testosterone on postoperative pain and opioid use are mediated by immune factors
Description
After signing the consent and assent forms, participants and their parents/guardians will complete several surveys, including demographic, behavioral, pain, substance use and analgesic risk assessment measures, and developmental surveys. In addition, a blood sample (for hormonal and immune analyses) will be collected on the day of the surgery and/or postoperative. Surgery-related parameters including postoperative pain, and opioid type and doses during the hospital time will be collected. In addition, before or after the surgery, patients and their parents/guardians will be interviewed. The i…
Eligibility
- Age range
- 11–16 years
- Sex
- Female
- Healthy volunteers
- Not specified
Inclusion Criteria: Pediatric female patients between the ages 11-16 undergoing an orthopedic (trauma and non-trauma) surgical procedure involving a long bone or joint, or the spine, English speaking Exclusion Criteria: Pregnancy; Diagnosis of chronic pain, Psychiatric, developmental or neurological disorders, Disorders that are associated with pubertal maturation (e.g., precocious puberty).
Interventions
- BehavioralPain
Postoperative pain levels
- BehavioralOpioid use
Postoperative opioid use
Location
- Washington University School of MedicineSt Louis, Missouri