A Phase 1/2 Study to Evaluate CHM-2101, an Autologous Cadherin 17 (CDH17) Chimeric Antigen Receptor (CAR) T Cell Therapy for the Treatment of Relapsed or Refractory Gastrointestinal Cancers
Chimeric Therapeutics
Summary
The goal of this clinical trial is to evaluate CHM-2101, an autologous CDH17 CAR T-cell therapy for the treatment of advanced gastrointestinal (GI) cancers that are relapsed or refractory to at least 1 standard treatment regimen in the metastatic or locally advanced setting.
Description
This is a Phase 1/2 open-label study to evaluate CHM-2101, an autologous CDH17 CAR T-cell therapy for the treatment of advanced gastrointestinal (GI) cancers that are relapsed or refractory to at least 1 standard treatment regimen in the metastatic or locally advanced setting. The study has 2 parts: Phase 1, Dose Escalation and Expansion, and Phase 2. Potential participants will provide written consent and be screened for study eligibility prior to undergoing any screening procedures, including leukapheresis. Protocol-specified criteria must be met prior to the start of leukapheresis for coll…
Eligibility
- Age range
- 18–85 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Documented informed consent of the participant and/or legally authorized representative. 2. Confirmed histologic diagnosis of one of the following solid tumors of GI origin: 1. Gastric adenocarcinoma Note: for gastric adenocarcinoma patients only, central laboratory confirmation of CDH17+ tumor expression is required. 2. Colon and/or rectal adenocarcinoma 3. G1, G2, and well-differentiated G3 neuroendocrine tumors of the midgut and hindgut (ileal, jejunal, cecal, distal colonic, or rectal; with ≤ 55% Ki67 expression) 3. Availability of unstained tumor tissue s…
Interventions
- BiologicalCHM-2101 CAR-T cells
Cadherin 17 (CDH17) Chimeric Antigen Receptor (CAR)-positive T cells
Locations (4)
- Emory UniversityAtlanta, Georgia
- University of ChicagoChicago, Illinois
- University of PennsylvaniaPhiladelphia, Pennsylvania
- Sarah Cannon Research InstituteNashville, Tennessee