The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)

Yale University

Summary

This proposed study is a double-blind, randomized, placebo-controlled, parallel-group, laboratory study to determine the effects of DMT, plus psychotherapy, on Alcohol Use Disorder.

Description

This study is a placebo-controlled, randomized, double blind, clinical trial to investigate the safety, tolerability and efficacy of the psychedelic dimethyltryptamine (DMT), in addition to a short course of psychotherapy, on Alcohol Use Disorder (AUD). The investigators hypothesize that relative to control (0.2 mg/kg/min + Dimethyltryptamine 0.01mg/kg/min infusion plus psychotherapy), a single psychedelic dose of DMT (plus psychotherapy) in individuals with AUD will 1) be safe and 2) well-tolerated, and 3) reduce alcohol consumption measured in the laboratory the day after, and over the follo…

Eligibility

Age range: 21–65 years
Sex: All
Healthy volunteers: No

Detailed criteria

Inclusion Criteria: * Diagnostic and Statistical Manual of Mental Disorders-5th edition (DSM-5) diagnosis of Alcohol Use Disorder * Medically healthy * Ability to provide consent Exclusion Criteria: * Unstable medical conditions

Interventions

Drug
0.3mg/kg/min Dimethyltryptamine + Normal Saline infusion
Infusion
Drug
0.2 mg/kg/min + Dimethyltryptamine 0.01mg/kg/min infusion
Infusion
Drug
25 mg Diphenhydramine (5 min) + Normal Saline
Infusion

Location

Connecticut Mental Health Center
New Haven, Connecticut
anahita.bassirnia@yale.edu