Memorial Sloan Kettering Cancer Center
The researchers are doing this study to find out if the study drug, enzalutamide, alone or combined with the study drug, mifepristone, is effective in treating advanced or metastatic androgen receptor-positive (AR+) triple negative breast cancer (TNBC) or estrogen receptor-low breast cancer (ER-low BC), and whether these study treatments work as well as standard chemotherapy with carboplatin, paclitaxel, capecitabine, or eribulin.
Inclusion Criteria: Screening Cohort (non-MSK patients only): * Age ≥18 years at time of consent * signed the pre-screening informed consent document to allow for AR testing as part of study screening Treatment Cohort: * Female or male * Pathologically confirmed invasive breast cancer that is unresectable, locally advanced, or metastatic * TNBC (ER/PgR \<1%) or ER-low defined as: * ER and PgR 1-10% * HER2 negative per American Society of Clinical Oncology/College of American Pathologists guidelines * Local testing for ER/PgR and HER2 is acceptable for eligibility. * Tumor must be…
mouth once daily (160 mg/day)
mouth once daily 300-mg tablet
The treating physician must select from one of the following regimens: * Eribulin 1.4 mg/m2 IV Day 1 and Day 8 in a 21-day cycle * Capecitabine 1000-1250 mg/m2 twice daily, orally Day 1-14 in a 21-day cycle * Paclitaxel 80 mg/m2 IV Day 1, Day 8 in a 21-day cycle * Carboplatin AUC 6 IV Day 1 in a 21-day cycle * Carboplatin AUC 2 IV Day 1, Day 8 and Day 15 in a 21-day cycle