A Clinical Trial of Adaptive Treatment for Early Smoking Cessation Relapse

Summary

This is a research study to find out if treatment decision making can be improved for smokers who find it difficult to quit with medications. Everyone who participates in this study will receive free product, either nicotine replacement therapies (patches and lozenges), varenicline, or a harm reduction product (e-cigarette) for a full 12 weeks. Most participants will receive some combination of these treatments, depending on individual response to each. All visits and study assessments will be entirely remote. All treatments will be provided free of charge for the first 12 weeks. After that, the study team will contact the participants 6 months after the first study phone call to complete another survey. The study lasts six months and will involve 8 surveys.

Description

Eligibility

Age range

21+ years

Sex

All

Healthy volunteers

Yes

Interventions

• Behavioral
  Switching to a different medication

  Participants will receive four weeks of the other FDA approved option, either varenicline or combination NRT, with instructions to try to quit again at week 4.

• Behavioral
  Continued use of the same medication

  Participants will receive four additional weeks of the same medication (varenicline or NRT) with instructions to try to quit again at week 4.

• Behavioral
  Switching to a harm reduction tobacco product

  Participants will receive four weeks of e-cigarette products with instructions to switch completely at Week 8

Location