A Phase 1, Multicenter, Open-label Study to Evaluate the Safety and Preliminary Efficacy of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma and Determine the Recommended Dose for Each Add-on Investigational Component
Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
Summary
The purpose of this study is to establish a safe and tolerable dose of arlocabtagene autoleucel (BMS-986393) in combinations with alnuctamab, mezigdomide, iberdomide, and elranatamab in participants with relapsed and/or refractory multiple myeloma (RRMM).
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * History of relapsed and/or refractory multiple myeloma (RRMM) treated with at least 3 (Part 1) or at least 1 but not greater than 3 prior anti-myeloma treatment regimens (Part 2). * Measurable multiple myeloma (MM) as per International Myeloma Working Group (IMWG). * Eastern Cooperative Oncology Group performance status of 0-1. Exclusion Criteria: * Prior treatment with alnuctamab (Arm A), mezigdomide (Arm B), iberdomide (Arm C), elranatamab (Arm D) or BCMA-targeting therapy (Part 2 Arms A and D). * Prior treatment with GPRC5D-targeting therapies. * Other protocol-defi…
Interventions
- DrugBMS-986393
Specified dose on specified days
- DrugAlnuctamab
Specified dose on specified days
- DrugMezigdomide
Specified dose on specified days
- DrugIberdomide
Specified dose on specified days
- DrugElranatamab
Specified dose on specified days
Locations (19)
- University of Alabama at BirminghamBirmingham, Alabama
- Mayo Clinic in Arizona - PhoenixPhoenix, Arizona
- City of Hope Comprehensive Cancer CenterDuarte, California
- Mayo Clinic in FloridaJacksonville, Florida
- Northside HospitalAtlanta, Georgia
- Beth Israel Deaconess Medical CenterBoston, Massachusetts