Effect of Ketamine on Intraoperative Motor Evoked Potentials
University of California, San Francisco
Summary
The goal of this clinical trial is to learn about the effect of ketamine on intraoperative motor evoked potentials in adult patients undergoing thoracolumbar spinal fusions. Participants will undergo a standard anesthetic. In addition to the standard anesthetic, the patients will be administered increasing doses of ketamine with motor-evoked potentials being measured at each dose, to assess any impacts.
Description
Spinal surgeries continue to increase in frequency and complexity. An important safety protocol is the use of intraoperative motor evoked potentials (MEP) to monitor the integrity and function of the spinal cord and alert the surgeon of any potential injury. Transcranial electric motor evoked potentials stimulate the motor cortex and produce a myogenic response. This modality can assess the function of all pathways including the motor cortex, the lateral corticospinal tracts, the function of the alpha motor neurons, and peripheral nerves. Various anesthetic agents can impact the critical para…
Eligibility
- Age range
- 18–100 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Adult patients (\>18 years of age) undergoing posterior spinal fusions. Exclusion Criteria: * Sensitivity or allergy to ketamine. * Schizophrenia or other psychotic conditions * Uncontrolled hypertension with systolic blood pressure greater than 180 mmHg * Myocardial Infarction * Large vascular aneurysms * Patients on ketamine as outpatient therapy.
Interventions
- DrugKetamine
Patients will be administered ketamine at increasing doses followed by measurements of motor-evoked potentials.
Location
- University of California, San FranciscoSan Francisco, California