Changes in Rate of Hemorrhage With Prophylactic Oxytocin for Second Trimester Dilation and Evacuation in the Clinic Setting

University of Colorado, Denver

Summary

The purpose of this study is to assess the effectiveness of prophylactic oxytocin on hemorrhage rates for second trimester dilation and evacuation (D\&E) in the clinic setting.

Eligibility

Age range: 18–55 years
Sex: Female
Healthy volunteers: Yes

Detailed criteria

Inclusion Criteria: * clinic-based D\&E at 18 weeks gestational age and above * speaks English or Spanish Exclusion Criteria: * refuses IV * history of coagulopathy * anticoagulant use in the preceding five days * chorioamnionitis or sepsis * suspected placenta accreta spectrum * intrauterine fetal demise * multiple gestation * use of misoprostol for cervical preparation

Interventions

Drug
Oxytocin + normal saline
40 units IV oxytocin once in a 1000 mL bag of normal saline
Drug
Normal saline
1000 mL bag of normal saline alone

Location

Comprehensive Women's Health Center
Denver, Colorado