University of California, San Francisco
The PLUM Study is a randomized, double-blinded, 2-arm, parallel-group, placebo-controlled trial is designed to compare the efficacy of letrozole versus placebo on leiomyoma-related symptoms and quality of life as well as leiomyoma and uterine size.
Inclusion Criteria: * At least 21 and less than 54 years of age (to focus on an adult, premenopausal population) * Female sex, based on sex identified on their birth certificate (no other gender requirements) * Have uterine leiomyomata that have been visualized on pelvic imaging (i.e., ultrasound or MRI) in the last 24 months * Report symptoms associated with leiomyomata such as heavy uterine bleeding, pelvic pressure or discomfort, urinary or bowel abnormalities, or dyspareunia for the past 3 months * Have at least moderate leiomyomata symptom burden, with UFS-QOL SSS score of 30 or higher a…
Oral letrozole 2.5mg/day
Placebo capsule
Arctuva estimate
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