A Novel Probiotic-antibiotic Combination to Prevent Recurrent Urinary Tract Infections
Ann & Robert H Lurie Children's Hospital of Chicago
Summary
Patients with recurrent UTI were randomized to receive either the probiotic Sacchromyces Boulardii at enrollment, and the intracellularly active Ciprofloxacin with their first UTI episode after enrollment, or they received standard of care treatment.
Description
* At the time of consent, participants will be given 20 mg/kg of the antibiotic, ciprofloxacin. If the participant has symptoms of a UTI or have a positive urine culture at enrollment, they will take the antibiotic every 12 hours for 14 days. If the participant does not have symptoms of a UTI at enrollment, the antibiotic will be taken only if needed at home upon the first occurrence of a UTI. * At the time of consent, participants will also be given 250 mg of the probiotic, S. boulardii, taken once daily for 6 months, irrespective of symptoms. \- Throughout the study, participants will rece…
Eligibility
- Age range
- 2–17 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * A history of 3 or more UTI episodes in the past 12 months, or 2 or more episodes in the past 6 months * no evidence of vesicoureteral reflux or only low-grade (grade 1-2) vesicoureteral reflux * no other genitourinary anatomical abnormality * not receiving prophylactic antibiotics at the time of enrollment * Ages 2-17 years. Exclusion Criteria: * high grade (grade 3-5) vesicoureteral reflux * neurogenic bladder * anatomical abnormalities of the gastrointestinal tract * any history of urologic or gastrointestinal surgery * on prophylactic antibiotics * a urine culture p…
Interventions
- DrugSaccharomyces Boulardii 250 MG [Florastor]
All patients will get the probiotic to be taken daily. If UTI occurs with a sensitive pathogen, we will treat with ciprofloxacin
Location
- Lurie Children's HospitalChicago, Illinois