Longitudinal Neural Fingerprinting of Opioid-use Trajectories
Yale University
Summary
This project aims to collect a densely sampled neuroimaging dataset among individuals receiving medications for opioid use disorder (MOUD). MOUD is multiphasic, comprised of medication induction, stabilization, ongoing treatment, and eventual dis-continuation phases. However, with a few small exceptions, existing neuroimaging efforts are almost exclusively single time-point assessments which, by definition, fail to capture these clinically relevant transitions and thus also do not capture individual risk and resilience trajectories. The investigators innovation, the characterization of neurocomputational trajectories during clinically relevant phases of MOUD treatment, will provide unprecedented mechanistic insight into the neurobiological basis of recovery. Once characterized, such trajectories may be used in the identification of specific therapeutic windows for additional intervention (e.g., times of increased neural plasticity) and in the design of novel tailored interventions based on known brain mechanisms (e.g., behavioral therapy, neurostimulation, neurofeedback).
Description
MOUD individuals between the ages of 18 and 50 who recently enrolled in methadone treatment at APT Foundation clinics in the greater New Haven area. Investigators will aim to recruit individuals as early as possible in treatment, but individuals may be within the first 6 months of treatment at the time of screening, as this may be necessary to ensure that they are on a stable dose of methadone. AIM 1 - Longitudinal neural fingerprinting of MOUD to repeatedly characterize neural trajectories of individuals in early methadone treatment. AIM 2 - Complementary, longitudinal computational phenoty…
Eligibility
- Age range
- 18–50 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * within the first 6 months of methadone treatment for OUD and on a stable dose of methadone * eligibility for MRI scanning * willing to commit to longitudinal study visits Exclusion Criteria: * current psychosis, mania, or suicidal ideation with intent, as assessed during screening with the SCID-5 * current co-occurring severe substance-use disorders (excluding nicotine and opioids), as assessed during screening with the SCID-5 * current intoxication or acute withdrawal at time of study visit sufficient to prevent participation based on: behavioral observation, breathal…
Interventions
- Diagnostic TestfMRI
Participants will be performing tasks while undergoing fMRI. Tasks include Stroop task, Emotion-regulation task and an Ambiguity reward task. There will also be a Resting state: Participants are not presented with any specific stimulus.
Location
- MRRC at The Anlyan CenterNew Haven, Connecticut