The ICE Study: Perceptions of E-Cigarettes and Synthetic Cooling Agents (R01)
Ohio State University Comprehensive Cancer Center
Summary
This study evaluates how synthetic cooling additives like WS-3 and WS-23 impact e-cigarette perceptions, use behavior, and toxicant exposure.
Description
PRIMARY OBJECTIVES: I. Assess the abuse liability of e-liquids with and without the presence of synthetic cooling agents. II. Determine the impact of synthetic cooling agents and flavor on EC puffing behavior (topography). III. Determine the exposure ranges (harmful and potentially harmful constituents \[HPHCs\], other toxicants) from vaping e-liquids with and without the presence of synthetic cooling agents. OUTLINE: Participants attend 4 sessions where they receive 1 of 4 randomly assigned flavored e-cigarettes. Participants use the e cigarettes for vaping followed by ad libitum vaping.…
Eligibility
- Age range
- 21–29 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Aged 21-29 years * Current e-cigarette (EC) user (defined as ≥ weekly use over the past 3 months) * Willing to provide informed consent and abstain from using their EC at least 12 hours prior to the four lab sessions * Read and speak English Exclusion Criteria: * Recently COVID-19+ (defined as positive test in the past 30 days) or a recent COVID-19 hospitalization (defined as a hospitalization within the past 6 months) * Unstable or significant psychiatric conditions (past and stable conditions will be allowed) * History of cardiac event or distress within the past 3 m…
Interventions
- BehavioralBehavioral Intervention
Receive and use flavored e-cigarettes (EC) as directed
- OtherBiospecimen Collection
Undergo biosample sample collection
- OtherSurvey Administration
Complete surveys
Location
- Ohio State University Comprehensive Cancer CenterColumbus, Ohio