M.D. Anderson Cancer Center
To learn if the combination of axicabtagene ciloleucel (axi-cel) and glofitamab as first-line therapy in high-risk LBCL participants or as second-line therapy in LBCL participants can help to control the disease.
Primary Objectives * To evaluate the safety of axicabtagene ciloleucel (axi-cel) and glofitamab as combination therapy in 2nd line LBCL participants * To evaluate the effect of axi-cel and glofitamab as combination therapy on the best complete response rate in 2nd line LBCL participants Secondary Objectives * To evaluate the effect of axi-cel and glofitamab as combination therapy on overall survival (OS) in 2nd line LBCL participants * To evaluate the effect of axi-cel and glofitamab as combination therapy on progression free survival in 2nd line LBCL participants * To evaluate the effect o…
Inclusion Criteria: * Histologically proven CD19- and CD20-positive LBCL, including transformation from indolent lymphomas. * Have disease that is refractory to or relapsed \<=12 months after the completion of first-line chemoimmunotherapy • Refractory disease defined as no complete response (CR) to first-line therapy; participants who are intolerant to first-line therapy are excluded * Progressive disease (PD) as best response to first-line therapy * Stable disease (SD) as best response after at least 4 cycles of first-line therapy (e.g., 4 cycles of R-CHOP) * Partial response (PR) as bes…
Given by IV
Given by IV
Given by IV
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