A Prospective, Open Label, Single-Arm, Multi-Center Study Evaluating Cryopreserved Osteochondral Allograft Cores for the Treatment of Osteochondral Lesions in the Knee
AlloSource
Summary
The primary objective of this study is to obtain evidence of the effectiveness of Cryopreserved Osteochondral Allograft Core in the treatment of osteochondral lesions on the femoral condyle.
Description
Patients between the ages of ≥12 years and ≤ 60 years who have a symptomatic full-thickness cartilage lesion (Grade 3 or 4) on the femoral condyle, in a mechanically stable knee, or is being mechanically stabilized in the same procedure, between 0.9-8.0 cm2 in size, and cystic changes requiring osseous repair, as confirmed by MRI , CT scan, or arthroscopy, and undergoing an osteochondral transplant procedure will be eligible for enrollment. Patients will receive one or more cryopreserved osteochondral allograft core transplants to replace damaged cartilage. Patients will be followed for up to…
Eligibility
- Age range
- 12–60 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Patients are ≥12 years and ≤ 60 years of age at the time of surgery. * Symptomatic patient presenting with moderate to severe pain in the index knee - unresponsive to conservative treatment (i.e., medication, bracing, physical therapy) and/or previous surgical intervention OR unsalvageable lesion that requires transplantation at the discretion of the treating physician. * Radiographically diagnosed, by MRI or CT scans, or through arthroscopy, to have a cartilage defect on the femoral condyle between 0.9-8.0 cm2 in size. * Will be having an osteochondral transplant proced…
Interventions
- Procedureosteochondral transplant on the femoral condyle
Patients between the ages of ≥12 years and ≤ 60 years who have a symptomatic full-thickness cartilage lesion (Grade 3 or 4) on the femoral condyle, in a mechanically stable knee, or is being mechanically stabilized in the same procedure, between 0.9-8.0 cm2 in size, and cystic changes requiring osseous repair, as confirmed by MRI , CT scan, or arthroscopy and will undergo a osteochondral transplant by removing the damaged cartilage and replacing that cartilage with a cryopreserved osteochondral allograft core.
Locations (6)
- Banner- University Medical Center- Phoenix Orthopedic and Sports Medicine InstitutePhoenix, Arizona
- Cedars-Sinai Kerlan Jobe InstituteLos Angeles, California
- Stanford Medicine-Orthopaedics and Sports Medicine in Redwood CityRedwood City, California
- University of California San FranciscoSan Francisco, California
- Rush Copley Medical CenterAurora, Illinois
- University of Kentucky Research FoundationLexington, Kentucky