Phase 1a/1b Study of BG-C9074, an Antibody Drug Conjugate Targeting B7H4, as Monotherapy and in Combination With Other Anticancer Therapies in Patients With Advanced Solid Tumors
BeOne Medicines
Summary
This is a first-in-human, dose finding and dose expansion study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of BG-C9074 alone and in combination with other anticancer therapies in patients with advanced solid tumors.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Able to provide a signed and dated written informed consent prior to any study-specific procedures, sampling, or data collection. 2. Eastern Cooperative Oncology Group (ECOG) Performance Status ≤ 1. 3. Participants with selected histologically or cytologically confirmed advanced, metastatic, and unresectable solid tumors who have previously received standard systemic therapy and whose cancer is not amenable to therapy with curative intent, and for whom further treatment is not available or not tolerated. Enrollment will be limited to participants with hormone receptor-p…
Interventions
- DrugBG-C9074
administered by intravenous infusion
- DrugTislelizumab
administered by intravenous infusion
- DrugBevacizumab
administered by intravenous infusion
Locations (38)
- Usc Norris Comprehensive Cancer Center (Nccc)Los Angeles, California
- University of Colorado Cancer CenterAurora, Colorado
- Florida Cancer Specialist Research Institute Lake NonaOrlando, Florida
- Sidney Kimmel Comprehensive Cancer At Johns HopkinsBaltimore, Maryland
- James Cancer Hospital and Solove Research InstituteColumbus, Ohio
- Blacktown Cancer and Haematology CentreBlacktown, New South Wales