University of North Carolina, Chapel Hill
The purpose of this study is to map the neural and molecular mechanisms underlying psychological stress-induced changes in inflammation which could reveal new targets for intervention to reduce the risk of cardiovascular disease.
The proposed work will conduct a mechanistic clinical trial utilizing the non-selective beta-adrenergic receptor blocker propranolol to examine the role of beta-adrenergic signaling in shaping neural and inflammatory responses to stress. The investigators will focus on beta-adrenergic signaling given seminal pre-clinical work showing that this molecular pathway is an important driver of stress-related increases in inflammation, and initial human neuroimaging work showing that beta-blockade leads to changes in neural responses to negative stimuli. Here, the investigators will bring these two pr…
Inclusion Criteria: * Ages 18-30 years * Right-handed * Fluent in English reading, writing, and speaking at least at a 10th grade level * Body mass index (BMI) less than or equal to 35 kg/m\^2 Exclusion Criteria: Assessed as screening, reassessed at Session I: * Non-removeable metal devices/implants/objects in the body * Severe claustrophobia (assessed by self-report) * Currently pregnant * Left-handed * Body mass index (BMI) greater than 35 kg/m\^2 * History of fainting spells or any heart condition * History of or present low resting heart rate (\< 60 BPM) and/or low blood pressure (syst…
Tablet encapsulated to visually look identical to the placebo.
Encapsulated sugar pill to visually look identical to the experimental condition.
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