Comparing Single Versus Repeat Parent-to-Child Nasal Microbiome Transplant on Seeding, Engraftment, and Diversity of the Neonatal Nasal Microbiome
Johns Hopkins University
Summary
This study aims to determine whether a parent-to-child nasal microbiota transplant (NMT) can seed and engraft parental organisms into the neonatal microbiome and increase the neonatal microbiome diversity.
Description
This parent-to-child NMT study will test the effect of an anterior nares, or nasal, microbiota transplant (NMT) on seeding, engraftment, and diversity of the neonatal microbiome. Neonates admitted to the Johns Hopkins Neonatal Intensive Care Unit (NICU) will be screened and parents will be approached for enrollment in the study. After consent and baseline screening of parents and neonates, eligible neonates will undergo an NMT.
Eligibility
- Age range
- 0–60 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: Neonate: 1. Neonate has anticipated NICU length of stay \> 7 days 2. Neonate ≥25 weeks gestation 3. At least one parent/adult provider not colonized with S. aureus (as determined by baseline screening) 4. Neonate is not colonized with S. aureus on baseline screening Parent/Adult provider: 1\. Parent/Adult provider is able to provide informed consent Exclusion Criteria: Neonate: 1. Neonate has had a prior clinical or surveillance culture grow S. aureus 2. Neonate is a ward of the State 3. Neonate with antenatal suspicion for immunodeficiency (e.g. sibling with known i…
Interventions
- BiologicalNasal Microbiota Transplant (NMT)
nasal microbiota transplant
- BiologicalPlacebo
Placebo sterile swab
Location
- Johns Hopkins UniversityBaltimore, Maryland