A Phase 1b Trial of Ivosidenib Combined With Ruxolitinib in IDH1-Mutated Advanced-Phase MPNs

Inclusion Criteria: * Advanced-Phase IDH1-mutated Ph-negative MPNs (both untreated and relapsed/refractory) including any of the following: * polycythemia vera with (PV) ≥ 5% peripheral or bone marrow blasts at time of screening * essential thrombocythemia (ET) with ≥ 5% peripheral or bone marrow blasts at time of screening * primary myelofibrosis (PMF) with ≥ 5% peripheral or bone marrow blasts at time of screening * Atypical CML with ≥ 5% peripheral or bone marrow blasts at time of screening * MPN-NOS with ≥ 5% peripheral or bone marrow blasts at time of screening * MDS/MPN Ove…