A Phase 2, Open-Label, Multicenter Study of Arlocabtagene Autoleucel (BMS-986393), a GPRC5D-directed CAR T Cell Therapy in Adult Participants With Relapsed or Refractory Multiple Myeloma (QUINTESSENTIAL)
Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
Summary
The purpose of this study is to evaluate the effectiveness and safety of Arlocabtagene Autoleucel (BMS-986393) in participants with relapsed or refractory multiple myeloma.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria * Documented diagnosis of multiple myeloma (MM) as per International Myeloma Working Group (IMWG) criteria. * Received at least 4 classes of MM treatment \[including immunomodulatory drug (IMiD), proteasome inhibitor (PI), anti CD38 mAb, anti-BCMA therapy, and at least 3 prior lines of therapy (LOT). * Documented disease progression during or after their last anti-myeloma regimen as per IMWG 2016 criteria. * Participants must have measurable disease during screening. * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. Exclusion Criteria * Active or h…
Interventions
- BiologicalArlocabtagene Autoleucel
Specified dose on specified days
Locations (52)
- University of Alabama at BirminghamBirmingham, Alabama
- Banner MD Anderson Cancer CenterGilbert, Arizona
- University of Arkansas for Medical SciencesLittle Rock, Arkansas
- UCLA Hematology/Oncology - Westwood (Building 200 Suite 214)Los Angeles, California
- UCSF Helen Diller Medical Center at Parnassus HeightsSan Francisco, California
- Colorado Blood Cancer InstituteDenver, Colorado