Sparking Gut Bacteria Production of Bioactive Xenolipids in Situ
University of California, Davis
Summary
Long-chain cyclopropane fatty acids (CpFAs) are microbially-derived lipids (fats), some of which can be found in select foods and appear to be produced naturally in the gut from dietary fatty acid precursors. Some of these lipids appear to have signaling properties in the body's tissues, i.e., to help regulate cardiometabolic health. Thus, increasing the bioavailability of CpFAs in humans may have utility to improve management of blood sugar and blood lipids, or to mitigate or prevent non-alcoholic fatty liver disease (NAFLD). This study is a proof-of-principle experiment in 10 subjects, to feed dietary fats thought to enhance upper gut CpFA production. The latter will be monitored through post-meal blood and urine CpFA concentration measurements, as well as concentration in the stool.
Eligibility
- Age range
- 18–50 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Men and women aged 18 to 50, with a Body Mass Index (BMI) categorized "normal" through "overweight" (18.5-29.9 kg/m2) and able to provide informed consent in English will be recruited to the study. Exclusion Criteria: * \- pregnancy or lactation * allergy or aversion to any of the foods that will be studied and/or provided * history of gastrointestinal disorders including ulcerative colitis, Crohn's disease, celiac sprue, hereditary non-polyposis colorectal cancer (HNPCC), familial adenomatous polyposis, pancreatic disease, or liver disease * history of any metabolic d…
Interventions
- Dietary SupplementDietary fat positive control
Dietary fat-containing meal plan with a specific supplement that may modify fat metabolism
- Dietary SupplementDietary fat negative control
Dietary fat-containing meal plan with a specific supplement that should not modify fat metabolism
Location
- University of California, Davis School of MedicineSacramento, California