University of Colorado, Denver
The investigators will evaluate the effects of an accelerated Transcranial Magnetic Stimulation (TMS) protocol of the left dorsolateral prefrontal cortex (DLPFC) for moderate to severe methamphetamine use disorder. This is a randomized parallel group design to assess feasibility and safety, evaluate efficacy (use, craving) and identify magnetic resonance imaging (resting state and cue craving) associated with group/outcomes.
In a randomized double-blind parallel-group sham-controlled design (n=20) administer a 5-day accelerated iTBS protocol (40 treatments) to the left dorsolateral prefrontal cortex during a short inpatient stay. Magnetic resonance imaging will be completed pre-post TMS and participants will be followed for 12 weeks.
Inclusion Criteria: 1. Age 21-65 years inclusive; 2. Meets DSM-5 criteria for past-year moderate or severe methamphetamine use disorder; 3. By Timeline Follow Back endorses at least 10 days of methamphetamine use out of the last month; 4. Provides a urine drug screen positive for methamphetamine; 5. Able to provide informed consent; 6. No change in current psychiatric medication regimen, or medication free, for at least 4 weeks prior to study entry; 7. Adequate English proficiency for study consent, and completion of the study instruments. Exclusion Criteria: 1. Lifetime non-substance-induc…
The TMS Cool-B65 A/P coil on its placebo side delivers electrical stimulation to the scalp (e.g., mimicking sensations associated with real stimulation) but does not provide magnetic stimulation to the targeted cortical structure.
The TMS Cool-B65 A/P coil delivers magnetic stimulation to targeted cortical structure.
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